Single Cell Methylomes Identify Neuronal Subtypes and Regulatory Elements in Mammalian Cortex

Science 357, 600 (2017)

Chongyuan Luo^1,2,†, Christopher L. Keown^3,†, Laurie Kurihara⁴, Jingtian Zhou^1,5, Yupeng He^1,5, Junhao Li³, Rosa Castanon¹, Jacinta Lucero⁶, Joseph R. Nery¹, Justin Sandoval¹, Brian Bui⁶, Terrence J. Sejnowski^2,6, Timothy Harkins⁴, Eran A. Mukamel^3,*, M. Margarita Behrens^6,*, Joseph R. Ecker^1,2,*

1. Genomic Analysis Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, United States.
2. Howard Hughes Medical Institute, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, United States.
3. Department of Cognitive Science, University of California, San Diego, La Jolla, CA 92037, United States.
4. Swift Biosciences Inc, 58 Parkland Plaza, Ste. 100, Ann Arbor, MI 48103, United States.
5. Bioinformatics Program, University of California, San Diego, La Jolla, CA 92093, United States.
6. Computational Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, United States.

Contact: emukamel [at] ucsd [dot] edu; mbehrens [at] salk [dot] edu; ecker [at] salk [dot] edu

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Data browsers: Mouse and Human tSNE browser Mouse genome browser (AnnoJ) Human genome browser (AnnoJ) User guide for the AnnoJ genome browser snmcseq: Data analysis code and tools for single nuclei methylation data (on Github) Data download GEO GSE97179 Processed data (5.7 GB) (README)

In the press:

• Salk Institute. "New kinds of brain cells revealed." ScienceDaily. ScienceDaily, 10 August 2017.
• UCSD News: Scientists Find New Way to Map Differences in the Brain

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Mouse and human brain cell types defined by DNA methylation: tSNE browser

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